Development of a Poly-e-Lysine Contact Lens as a Drug Delivery Device for the Treatment of Fungal Keratitis
نویسندگان
چکیده
Andrew G. Gallagher, Keri McLean, Rosalind M. K. Stewart, Don A. Wellings, Heather E. Allison, and Rachel L. Williams Department of Eye and Vision Science, Institute of Ageing and Chronic Diseases, University of Liverpool, Liverpool, United Kingdom SpheriTech Ltd., Runcorn, Cheshire, United Kingdom St. Paul’s Eye Unit, Royal Liverpool University Hospital, Liverpool, United Kingdom Department of Functional and Comparative Genomics, Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom
منابع مشابه
Immunology and Microbiology Development of a Poly-e-Lysine Contact Lens as a Drug Delivery Device for the Treatment of Fungal Keratitis
Andrew G. Gallagher, Keri McLean, Rosalind M. K. Stewart, Don A. Wellings, Heather E. Allison, and Rachel L. Williams Department of Eye and Vision Science, Institute of Ageing and Chronic Diseases, University of Liverpool, Liverpool, United Kingdom SpheriTech Ltd., Runcorn, Cheshire, United Kingdom St. Paul’s Eye Unit, Royal Liverpool University Hospital, Liverpool, United Kingdom Department of...
متن کاملDevelopment of a Poly-ε-Lysine Contact Lens as a Drug Delivery Device for the Treatment of Fungal Keratitis.
Purpose The purpose of this study was to develop a more efficient drug delivery device to overcome the limitations of current drop therapy for the treatment of fungal keratitis. Methods Amphotericin B (AmpB), 0 to 30 μg/mL, was associated with a poly-ε-lysine (pεK) hydrogel. Fungicidal effect against Candida albicans was assessed at 18 and 42 hours by optical density (OD600) and growth on aga...
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Background and Purpose: Fungal keratitis is a suppurative, ulcerative, and sight-threatening infection of the cornea that sometimes leads to blindness. The aims of this study were: recuperating facilities for laboratory diagnosis, determining the causative microorganisms, and comparing conventional laboratory diagnostic tools and semi-nested PCR. Materials and Methods: Sampling was conducted in...
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Nocardia farcinica is one of the more recently identified species of the Nocardia genus. Nocardia farcinica keratitis is a rare occurrence, with only eight previously reported cases. Semi-permeable rigid contact lens use was associated with one of these reported cases. We report the first case of an extended wear soft contact lens-related Nocardia farcinica keratitis and recommend a new treatme...
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Contact lens wearers are at great risk of developing microbial keratitis because of incorrect usages and unhygienic maintenance of contact lenses. Therefore, the present study was planned to provide data that will be helpful in selecting the anti-microbial to cure microbial keratitis. One hundred bacterial isolates from conjunctiva of contact lenses wearer were isolated, identified and subjecte...
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